Module 9: Discussion
A 38-year-old African-American woman was admitted for
arthroscopic knee surgery. Her hematocrit was 25%, blood pressure was 140/94 mm
Hg, and pulse was 112 beats/minute. She had a history of joint and bone pain,
jaundice, and abdominal pain.
Due to the presenting symptoms (joint and bone pain,
abdominal pain, and jaundice) a diagnosis of Sickle Cell Disease was
considered.
1. Provide a brief discussion of the pathophysiology of
sickle cell disease and discuss the clinical manifestations and the etiology
associated with each manifestation of this disease.
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