PHM450
Homework #3
1. Tetrodotoxin acts by:
A)Blocking potassium channels
B) Blocking sodium channels
C) Preventing acetylcholine release at the nerve
terminal
D) Preventing serotonin reuptake
2. Ecstasy has the dual action of increasing release
and blocking reuptake of:
A)Serotonin
B) Dopamine
C) Norepinephrine
D) All of the above
3. MPTP is metabolized into MPP+ by:
A)Astrocytes
B) Oligodendrocytes
C) Dopaminergic neurons
D) Myelin
4. Organophosphate pesticides act by:
A)Increasing release of acetylcholine
B) Preventing reuptake of acetylcholine
C) Mimicking acetylcholine
D) Inhibiting acetylcholinesterase
5. Botulinum toxin acts by:
A)Blocking release of acetylcholine
B) Preventing reuptake of acetylcholine
C) Mimicking acetylcholine
D) Inhibiting acetylcholinesterase
6. Compounds that cross the blood-brain barrier tend
to be:
A)Lipophilic
B) Non-polar
C) Low molecular weight
D) All of the above
7. Acetaminophen is metabolized by the following
Phase I enzyme:
A)Glucuronyl transferase
B) CYP2E1
C) CYP3A4
D) None of the above
8. The increased hepatic expression of CYP450 is
called:
A)Inhibition
B) Induction
C) Phase I reaction
D) Phase II reaction
9. The irreversible lesions that are characteristic
of cirrhosis result from deposition of __________ by fibroblasts.
A)Epithelial cells
B) Lipids
C) Bile acids
D) Collagen
10. The highest concentration of CYP450 enzyme in the
liver are found in:
A)Zone 1
B) Zone 2
C) Zone 3
D) Zone 4
11. The reactive intermediate formed when
acetaminophen undergoes Phase I metabolism is:
A)NAPQI
B) Isoniazid
C) CYP2E1
D) APAP
12. Vinyl chloride causes a rare form of liver tumor
called:
A)Cirrhosis
B) Hepatocellular carcinoma
C) Haemangiosarcoma
D) Centrilobular hepatic necrosis
13. The following enzyme is not measured in the serum
as an in vivo indicator of liver damage:
A)ALT
B) NAPQI
C) AST
D) LDH
14. Which segment of the nephron is the major site of
action for nephrotoxicants?
A)glomerulus
B) loop of Henle
C) proximal tubule
D) collecting duct
15. Damage to podocytes may cause which of the
following effects:
A)oliguria
B) acidosis
C) vasoconstriction
D) proteinuria
E) vasodilation
16. Metallothioneins do NOT bind which of the
following:
A)chloride
B) copper
C) gold
D) mercury
E) cadmium
17. Vasoconstriction of afferent arterioles leads to:
A)increased GFR
B) atherosclerosis
C) proteinuria
D) decreased GFR
E) polyuria
18. The primary lesion in analgesic nephropathy is:
A)glomerular capillary vasoconstriction
B) increased podocyte filtration slit size
C) brush border apoptosis
D) papillary necrosis
E) none of the above
19.
Chromium damages the proximal convoluted tubule, which results in:
A)increased organic anion secretion
B) decreased organic anion secretion
C) decreased glucose reabsorption
D) increased glucose reabsorption
E) increased sodium reabsorption
20. GFR can be measured directly by determining
clearance of:
A)insulin
B) creatinine
C) sodium
D) potassium
E) all of the above
